Imaging guided drug discovery

The goal of the Clark Lab is to develop new therapies for cancer and autoimmune disease.  The Clark Lab does this by learning from and levering positron emission tomography (PET) molecular imaging studies to discover critical pathways in these diseases, by using high-throughput screening efforts to identify new ways to target these pathways, and by further studying these pathways and inhibitors in cell culture and animal models.

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Glucose consumption mechanism. CDK7 regulates GLUT1 expression levels, glucose transport, and glucose consumption.

Lab News

December 2, 2019:  Our work describing a high-throughput method for discovering inhibitors of cellular glucose consumption and detailed studies of one inhibitor we identified is published at Nature Communications!  We also contributed a blog post about the studies to the Nature Research Cancer Community and were featured in a UCLA News Release!

December 2, 2019:  Our new website is launched!