Featured Publications

2019

Ghezzi C., Wong A., Chen B. Y., Ribalet B., Damoiseaux R., Clark P. M., “A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.” Nat Commun. 2019 10, (1), 5444.  Abstract

Chen B. Y., Ghezzi C., Villegas B., Quon A., Radu C. G., Witte O. N., Clark P.M., “18F-FAC PET visualizes brain-infiltrating leukocytes in a mouse model of multiple sclerosis. J. Nucl. Med. 2019 [Epub ahead of print].  Abstract

2018

Shin B. C., Cepeda C., Estrada-Sánchez A. M., Levine M. S., Hodaei L., Dai Y., Jung J., Ganguly A., Clark P., Devaskar S.U., “Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes.” J. Neurosci. 2018 38, (44), 9579-9599. Abstract

Salas J. R., Chen B. Y., Wong A., Cheng D., Van Arnam J. S., Witte O. N., Clark P.M., “18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis.” J. Nucl. Med. 2018 59, (10), 1616-1623. Abstract

Salas J. R., Chen B. Y., Wong A., Duarte S., Angarita S. A. K., Lipshutz G. S., Witte O. N., Clark P. M., “Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET.” J. Nucl. Med. 2018 59, (8), 1308-1315.  Abstract

2017

Nakano H., Minami I., Braas D., Pappoe H., Wu X., Sagadevan A., Vergnes L., Fu K., Morselli M., Dunham C., Ding X., Stieg A. Z., Gimzewski J. K., Pellegrini M., Clark P. M., Reue K., Lusis A. J., Ribalet B., Kurdistani S. K., Christofk H., Nakatsuji N., Nakano A., “Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.” Elife. 2017 6. pii: e29330. Abstract

Mai W. X., Gosa L., Daniels V. W., Ta L., Tsang J. E., Higgins B., Gilmore W. B., Bayley N. A., Harati M. D., Lee J. T., Yong W. H., Kornblum H. I., Bensinger S. J., Mischel P. S., Rao P. N., Clark P. M., Cloughesy T. F., Letai A., Nathanson D. A.,  “Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.” Nat. Med. 2017 23, (11), 1342-1351.  Abstract

Clark P. M., Ebiana V. A., Gosa L, Cloughesy T. F., Nathanson D. A., “Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine.” J. Nucl. Med. 2017 58, (5), 689-696.  Abstract

Dai Y., Zhao Y., Tomi M., Shin B. C., Thamotharan S., Mazarati A., Sankar R., Wang E. A., Cepeda C., Levine M. S., Zhang J., Frew A., Alger J. R., Clark P. M., Sondhi M., Kositamongkol S., Leibovitch L., Devaskar S. U., “Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability.” Endocrinology. 2017 158, (4), 936-949.  Abstract

2016

Clark, P. M.; Mai, W. X.; Cloughesy, T. F.; Nathanson D. A., “Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.” Curr. Neurol. Neurosci. Rep. 2016. 16, (2), 17.  Abstract

Faltermeier, C. M.; Drake, J. M.; Clark, P. M.; Smith, B. A.; Zong Y.; Volpe, C.; Mathis, C.; Morrissey, C.; Castor, B.; Huang, J.; Witte O. N., “Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.” Proc. Natl. Acad. Sci. USA. 2016. 113, (2), E172-181.  Abstract

Before 2016

Clark, P. M.*; Evdokimov, N. M.*; Flores, G.; Chai, T.; Faull, K. F.; Phelps, M. E.; Witte, O. N.; Jung, M. E., “Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo.” J. Med. Chem. 2015, 58, (14), 5538-47.  Abstract

Clark, P. M.; Flores, G.; Evdokimov, N. M.; McCracken, M. N.; Chai, T.; Nair-Gill, E.; O’Mahony, F.; Beaven, S. W.; Faull, K. F.; Phelps, M. E.; Jung, M. E.; Witte, O. N., “Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver.” Proc. Natl. Acad. Sci. USA. 2014, 111, (28), E2866-E2874.  Abstract

Evdokimov, N. M.; Flores, G.; Clark, P. M.; Phelps, M. E.; Witte, O. N.; Jung, M. E., “5- (2-[18F]fluoroethyl)-4-methylthiazole probe for positron emission tomography of the central nervous system.” Chem. Heterocycl. Compd. 2014, 50, (2), 303-307.  Abstract

Clark, P. M.*; Rexach, J. E.*; Hsieh-Wilson, L. C., “Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags.” Curr. Protoc. Chem. Biol. 2013, 5, (4), 281-302.  Abstract

Ramakrishnan, P.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Hsieh-Wilson, L. C.; Baltimore, D., “Activation of the Transcriptional Function of the NF-kappaB Protein c-Rel by O-GlcNAc Glycosylation.” Sci. Signal. 2013, 6,(290), ra75.  Abstract

Yi, W.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Driggers, E. M.; Hsieh-Wilson, L. C., “Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism.” Science. 2012, 337, (6097), 975-980.  Abstract

Clark, P. M.*; Rexach, J. E.*; Mason D. E.; Neve, R. L.; Peters, E. C.; Hsieh-Wilson, L. C., “Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.” Nature Chem. Biol. 2012, 8, (3), 253-61.  Abstract

Clark, P. M.*; Rogers, C. J.*; Tully, S. E.; Abrol, R; Garcia, K. C.; Goddard, W. A., 3rd; Hsieh-Wilson, L. C., “Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.” Proc. Natl. Acad. Sci. USA 2011, 108, (24), 9747-52.  Abstract

Clark, P. M.; Dweck, J. F.; Mason D. E.; Hart C. R.; Buck S. B.; Peters E. C.; Agnew B. J.; Hsieh-Wilson L. C., “Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.” J. Am. Chem. Soc. 2008, 130, 11576-7.  Abstract

Clark, P. M.*; Rexach, J. E.*; Hsieh-Wilson, L. C., “Chemical approaches to understanding O-GlcNAc glycosylation in the brain.” Nature Chem. Biol. 2008, 4, (2), 97-106.  Abstract

Khidekel, N.; Ficarro, S. B.; Clark, P. M.; Bryan, M. C.; Swaney, D. L.; Rexach, J. E.; Sun, Y. E.; Coon, J. J.; Peters, E. C.; Hsieh-Wilson, L. C., “Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.” Nature Chem. Biol. 2007, 3, (6), 339-48.  Abstract

Gama, C. I.; Tully, S. E.; Sotogaku, N.; Clark, P. M.; Rawat, M.; Vaidehi, N.; Goddard, W. A., 3rd; Nishi, A.; Hsieh-Wilson, L. C., “Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.” Nature Chem. Biol. 2006, 2, (9), 467-73.  Abstract

Clark, P. M.; Lee, S.; Fredrickson, D. C., “Transition metal AB3 intermetallics: Structure maps based on quantum mechanical stability.” J. Solid State Chem. 2005, 178, (4), 1269-1283.  Abstract

* Co-first author