Featured Publications
2023
Ghezzi C, Chen BY, Damoiseaux R, Clark PM. Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3. Sci Rep. 2023 Jan 25;13(1):1442. doi: 10.1038/s41598-023-28576-2. PMID: 36697489; PMCID: PMC9876922. Abstract
Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. Immunology. 2023 Jan;168(1):152-169. doi: 10.1111/imm.13569. Epub 2022 Sep 4. PMID: 35986643; PMCID: PMC9844239. Abstract
2022
Ghezzi C, Perez S, Ryan K, Wong A, Chen BY, Damoiseaux R, Clark PM. Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells. Mol Imaging Biol. 2022 Oct 25. doi: 10.1007/s11307-022-01782-6. Epub ahead of print. PMID: 36284040. Abstract
Salas JR, Clark PM. Signaling Pathways That Drive 18F-FDG Accumulation in Cancer. J Nucl Med. 2022 May;63(5):659-663. doi: 10.2967/jnumed.121.262609. Epub 2022 Mar 3. PMID: 35241480. Abstract
2021
Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 Apr 21;11(1):8669. doi: 10.1038/s41598-021-88159-x. PMID: 33883682; PMCID: PMC8060418. Abstract
2020
Lisova K, Chen BY, Wang J, Fong KM, Clark PM, van Dam RM. Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). EJNMMI Radiopharm Chem. 2019 Dec 31;5(1):1. doi: 10.1186/s41181-019-0082-3. PMID: 31893318; PMCID: PMC6938530. Abstract
Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med Chem Lett. 2020 May 1;11(10):1799-1809. doi: 10.1021/acsmedchemlett.9b00599. PMID: 33062157; PMCID: PMC7549123. Abstract
Chen BY, Ghezzi C, Villegas B, Quon A, Radu CG, Witte ON, Clark PM. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020 May;61(5):757-763. doi: 10.2967/jnumed.119.229351. Epub 2019 Oct 25. PMID: 31653711; PMCID: PMC7198381. Abstract
Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):563-572. doi: 10.1073/pnas.1915770117. Epub 2019 Dec 23. PMID: 31871155; PMCID: PMC6955337. Abstract
2019
Ghezzi C, Wong A, Chen BY, Ribalet B, Damoiseaux R, Clark PM. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019 Nov 29;10(1):5444. doi: 10.1038/s41467-019-13334-8. PMID: 31784510; PMCID: PMC6884612 Abstract
2018
Shin BC, Cepeda C, Estrada-Sánchez AM, Levine MS, Hodaei L, Dai Y, Jung J, Ganguly A, Clark P, Devaskar SU. Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes. J Neurosci. 2018 Oct 31;38(44):9579-9599. doi: 10.1523/JNEUROSCI.0503-18.2018. Epub 2018 Sep 19. PMID: 30232223; PMCID: PMC6706001. Abstract
Salas JR, Chen BY, Wong A, Cheng D, Van Arnam JS, Witte ON, Clark PM. 18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis. J Nucl Med. 2018 Oct;59(10):1616-1623. doi: 10.2967/jnumed.118.210328. Epub 2018 Apr 26. PMID: 29700125; PMCID: PMC6167535. Abstract
Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM. Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET. J Nucl Med. 2018 Aug;59(8):1308-1315. doi: 10.2967/jnumed.117.206961. Epub 2018 Mar 1. PMID: 29496991; PMCID: PMC6071498. Abstract
2017
Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 Dec 12;6:e29330. doi: 10.7554/eLife.29330. PMID: 29231167; PMCID: PMC5726851. Abstract
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9. PMID: 29035366; PMCID: PMC5683421. Abstract
Clark PM, Ebiana VA, Gosa L, Cloughesy TF, Nathanson DA. Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine. J Nucl Med. 2017 May;58(5):689-696. doi: 10.2967/jnumed.116.181693. Epub 2017 Apr 6. PMID: 28385796. Abstract
Dai Y, Zhao Y, Tomi M, Shin BC, Thamotharan S, Mazarati A, Sankar R, Wang EA, Cepeda C, Levine MS, Zhang J, Frew A, Alger JR, Clark PM, Sondhi M, Kositamongkol S, Leibovitch L, Devaskar SU. Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology. 2017 Apr 1;158(4):936-949. doi: 10.1210/en.2016-1816. PMID: 28324109; PMCID: PMC5460805. Abstract
2016
Clark PM, Mai WX, Cloughesy TF, Nathanson DA. Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma. Curr Neurol Neurosci Rep. 2016 Feb;16(2):17. doi: 10.1007/s11910-015-0613-6. PMID: 26759318. Abstract
Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E172-81. doi: 10.1073/pnas.1521674112. Epub 2015 Nov 30. PMID: 26621741; PMCID: PMC4720329. Abstract
Before 2016
Clark PM*, Evdokimov NM*, Flores G, Chai T, Faull KF, Phelps ME, Witte ON, Jung ME. Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. J Med Chem. 2015, 58, (14), 5538-47. Abstract
Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O’Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc Natl Acad Sci USA. 2014, 111, (28), E2866-E2874. Abstract
Evdokimov NM, Flores G, Clark PM, Phelps ME, Witte ON, Jung ME. 5- (2-[18F]fluoroethyl)-4-methylthiazole probe for positron emission tomography of the central nervous system. Chem. Heterocycl. Compd. 2014, 50, (2), 303-307. Abstract
Clark PM*, Rexach JE*, Hsieh-Wilson LC. Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags. Curr Protoc Chem Biol. 2013, 5, (4), 281-302. Abstract
Ramakrishnan P, Clark PM, Mason DE, Peters EC, Hsieh-Wilson LC, Baltimore D. Activation of the Transcriptional Function of the NF-kappaB Protein c-Rel by O-GlcNAc Glycosylation. Sci Signal. 2013, 6,(290), ra75. Abstract
Yi W, Clark PM, Mason DE, Peters EC, Driggers EM, Hsieh-Wilson, LC. Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism. Science. 2012, 337, (6097), 975-980. Abstract
Clark PM*, Rexach JE*, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nature Chem Biol. 2012, 8, (3), 253-61. Abstract
Clark PM*, Rogers CJ*, Tully SE, Abrol R, Garcia KC, Goddard WA 3rd, Hsieh-Wilson LC. Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches. Proc Natl Acad Sci USA. 2011, 108, (24), 9747-52. Abstract
Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC. Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins. J Am Chem Soc. 2008, 130, 11576-7. Abstract
Clark PM*, Rexach JE*, Hsieh-Wilson LC. Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nature Chem Biol. 2008, 4, (2), 97-106. Abstract
Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. Nature Chem Biol. 2007, 3, (6), 339-48. Abstract
Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA 3rd, Nishi A, Hsieh-Wilson LC. Sulfation patterns of glycosaminoglycans encode molecular recognition and activity. Nature Chem Biol. 2006, 2, (9), 467-73. Abstract
Clark PM, Lee S, Fredrickson DC. Transition metal AB3 intermetallics: Structure maps based on quantum mechanical stability. J Solid State Chem. 2005, 178, (4), 1269-1283. Abstract
* Co-first author