Featured Publications

2021

Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 Apr 21;11(1):8669. doi: 10.1038/s41598-021-88159-x. PMID: 33883682; PMCID: PMC8060418. Abstract

2020

Lisova K, Chen BY, Wang J, Fong KM, Clark PM, van Dam RM. Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). EJNMMI Radiopharm Chem. 2019 Dec 31;5(1):1. doi: 10.1186/s41181-019-0082-3. PMID: 31893318; PMCID: PMC6938530. Abstract

Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med Chem Lett. 2020 May 1;11(10):1799-1809. doi: 10.1021/acsmedchemlett.9b00599. PMID: 33062157; PMCID: PMC7549123. Abstract

Chen BY, Ghezzi C, Villegas B, Quon A, Radu CG, Witte ON, Clark PM. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020 May;61(5):757-763. doi: 10.2967/jnumed.119.229351. Epub 2019 Oct 25. PMID: 31653711; PMCID: PMC7198381. Abstract

Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, Witte ON, Chin AI, Park JW. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):563-572. doi: 10.1073/pnas.1915770117. Epub 2019 Dec 23. PMID: 31871155; PMCID: PMC6955337. Abstract

2019

Ghezzi C, Wong A, Chen BY, Ribalet B, Damoiseaux R, Clark PM. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019 Nov 29;10(1):5444. doi: 10.1038/s41467-019-13334-8. PMID: 31784510; PMCID: PMC6884612 Abstract

2018

Shin BC, Cepeda C, Estrada-Sánchez AM, Levine MS, Hodaei L, Dai Y, Jung J, Ganguly A, Clark P, Devaskar SU. Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes. J Neurosci. 2018 Oct 31;38(44):9579-9599. doi: 10.1523/JNEUROSCI.0503-18.2018. Epub 2018 Sep 19. PMID: 30232223; PMCID: PMC6706001. Abstract

Salas JR, Chen BY, Wong A, Cheng D, Van Arnam JS, Witte ON, Clark PM. 18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis. J Nucl Med. 2018 Oct;59(10):1616-1623. doi: 10.2967/jnumed.118.210328. Epub 2018 Apr 26. PMID: 29700125; PMCID: PMC6167535. Abstract

Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM. Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET. J Nucl Med. 2018 Aug;59(8):1308-1315. doi: 10.2967/jnumed.117.206961. Epub 2018 Mar 1. PMID: 29496991; PMCID: PMC6071498.  Abstract

2017

Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 Dec 12;6:e29330. doi: 10.7554/eLife.29330. PMID: 29231167; PMCID: PMC5726851. Abstract

Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9. PMID: 29035366; PMCID: PMC5683421. Abstract

Clark PM, Ebiana VA, Gosa L, Cloughesy TF, Nathanson DA. Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine. J Nucl Med. 2017 May;58(5):689-696. doi: 10.2967/jnumed.116.181693. Epub 2017 Apr 6. PMID: 28385796.  Abstract

Dai Y, Zhao Y, Tomi M, Shin BC, Thamotharan S, Mazarati A, Sankar R, Wang EA, Cepeda C, Levine MS, Zhang J, Frew A, Alger JR, Clark PM, Sondhi M, Kositamongkol S, Leibovitch L, Devaskar SU. Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology. 2017 Apr 1;158(4):936-949. doi: 10.1210/en.2016-1816. PMID: 28324109; PMCID: PMC5460805.  Abstract

2016

Clark PM, Mai WX, Cloughesy TF, Nathanson DA. Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma. Curr Neurol Neurosci Rep. 2016 Feb;16(2):17. doi: 10.1007/s11910-015-0613-6. PMID: 26759318. Abstract

Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E172-81. doi: 10.1073/pnas.1521674112. Epub 2015 Nov 30. PMID: 26621741; PMCID: PMC4720329. Abstract

Before 2016

Clark, P. M.*; Evdokimov, N. M.*; Flores, G.; Chai, T.; Faull, K. F.; Phelps, M. E.; Witte, O. N.; Jung, M. E., “Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo.” J. Med. Chem. 2015, 58, (14), 5538-47.  Abstract

Clark, P. M.; Flores, G.; Evdokimov, N. M.; McCracken, M. N.; Chai, T.; Nair-Gill, E.; O’Mahony, F.; Beaven, S. W.; Faull, K. F.; Phelps, M. E.; Jung, M. E.; Witte, O. N., “Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver.” Proc. Natl. Acad. Sci. USA. 2014, 111, (28), E2866-E2874.  Abstract

Evdokimov, N. M.; Flores, G.; Clark, P. M.; Phelps, M. E.; Witte, O. N.; Jung, M. E., “5- (2-[18F]fluoroethyl)-4-methylthiazole probe for positron emission tomography of the central nervous system.” Chem. Heterocycl. Compd. 2014, 50, (2), 303-307.  Abstract

Clark, P. M.*; Rexach, J. E.*; Hsieh-Wilson, L. C., “Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags.” Curr. Protoc. Chem. Biol. 2013, 5, (4), 281-302.  Abstract

Ramakrishnan, P.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Hsieh-Wilson, L. C.; Baltimore, D., “Activation of the Transcriptional Function of the NF-kappaB Protein c-Rel by O-GlcNAc Glycosylation.” Sci. Signal. 2013, 6,(290), ra75.  Abstract

Yi, W.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Driggers, E. M.; Hsieh-Wilson, L. C., “Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism.” Science. 2012, 337, (6097), 975-980.  Abstract

Clark, P. M.*; Rexach, J. E.*; Mason D. E.; Neve, R. L.; Peters, E. C.; Hsieh-Wilson, L. C., “Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.” Nature Chem. Biol. 2012, 8, (3), 253-61.  Abstract

Clark, P. M.*; Rogers, C. J.*; Tully, S. E.; Abrol, R; Garcia, K. C.; Goddard, W. A., 3rd; Hsieh-Wilson, L. C., “Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.” Proc. Natl. Acad. Sci. USA 2011, 108, (24), 9747-52.  Abstract

Clark, P. M.; Dweck, J. F.; Mason D. E.; Hart C. R.; Buck S. B.; Peters E. C.; Agnew B. J.; Hsieh-Wilson L. C., “Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.” J. Am. Chem. Soc. 2008, 130, 11576-7.  Abstract

Clark, P. M.*; Rexach, J. E.*; Hsieh-Wilson, L. C., “Chemical approaches to understanding O-GlcNAc glycosylation in the brain.” Nature Chem. Biol. 2008, 4, (2), 97-106.  Abstract

Khidekel, N.; Ficarro, S. B.; Clark, P. M.; Bryan, M. C.; Swaney, D. L.; Rexach, J. E.; Sun, Y. E.; Coon, J. J.; Peters, E. C.; Hsieh-Wilson, L. C., “Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.” Nature Chem. Biol. 2007, 3, (6), 339-48.  Abstract

Gama, C. I.; Tully, S. E.; Sotogaku, N.; Clark, P. M.; Rawat, M.; Vaidehi, N.; Goddard, W. A., 3rd; Nishi, A.; Hsieh-Wilson, L. C., “Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.” Nature Chem. Biol. 2006, 2, (9), 467-73.  Abstract

Clark, P. M.; Lee, S.; Fredrickson, D. C., “Transition metal AB3 intermetallics: Structure maps based on quantum mechanical stability.” J. Solid State Chem. 2005, 178, (4), 1269-1283.  Abstract

* Co-first author